Strategische hormonelle Fruchtbarkeitsprogramme bei Kühen

C. Schmidt; Z. Gajewski; A. Wehrend

doi:10.1055/s-0038-1623156

Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere, Table of Contents

Tierarztl Prax Ausg G Grosstiere Nutztiere 2013; 41(02): 95-104
DOI: 10.1055/s-0038-1623156

Übersichtsartikel

Schattauer GmbH

Strategische hormonelle Fruchtbarkeitsprogramme bei Kühen

Teil 2: Präsynchronisation und ResynchronisationStrategic hormonal reproductive programs in cowsPart 2: Presynchronization and resynchronization

Authors

C. Schmidt

¹Tierärztliche Klinik Dr. Eller, Hofheim i. Ufr.
Z. Gajewski

²Department of Large Animal Diseases with the Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland
A. Wehrend

³Klinikum Veterinärmedizin, Klinik für Geburtshilfe, Gynäkologie und Andrologie der Groß- und Kleintiere mit Tierärztlicher Ambulanz, Justus-Liebig-Universität Gießen

Abstract

Zusammenfassung

Gegenstand und Ziel: Beschreibung der Methoden der hormonellen Präsynchronisation und Resynchronisation beim Rind. Material und Methode: Literaturübersicht. Ergebnisse: Da die Trächtigkeitsrate von Kühen, die ein Ovsynch-Programm durchlaufen, entscheidend davon abhängt, in welchem Zyklusstadium sich die Tiere zu Beginn des Programms befinden, wurden verschiedene Methoden der Präsynchronisation entwickelt, die auf dem Einsatz von PGF_2α oder dem kombinierten Einsatz von PGF_2α und GnRH-Analoga beruhen. Ein weiteres Problem stellt die schnellstmögliche Besamung nicht tragender Kühe nach dem Ovsynch-Programm dar. Als Lösung wird die Behandlung aller Tiere nach der Besamung 7 Tage vor der Trächtigkeitsuntersuchung empfohlen. Stellt sich eine Kuh am Tag der Trächtigkeitsuntersuchung als nicht tragend dar, wird ihr PGF_2α verabreicht, um möglichst schnell eine erneute Insemination durchführen zu können. Klinische Relevanz: Durch den Einsatz von Programmen zur Präsynchronisation und Resynchronisation kann die Fruchtbarkeitsleistung einer Milchviehherde gesteigert werden.

Summary

Objective: Description of hormonal presynchronization and resynchronization methods in cattle. Material and methods: Review. Results: As the pregnancy rate of cows treated with the Ovsynch program primarily depends on the stage of the oestrous cycle at the time of program initiation, different methods of presynchronization based on the use of PGF_2α and combinations of PGF_2α and gonadotropin-releasing hormone analogues have been developed. An additional problem includes the earliest possible insemination of open cows following the Ovsynch program. As a solution to this problem a postinsemination treatment of all animals seven days before the scheduled date of the pregnancy ex amination is recommended.If a cow is found not to be pregnant by the pregnancy examination, it will be treated with PGF_2α to enable a fur ther insemination as soon as possible thereafter. Clinical relevance: By utilizing presynchronization and resynchronization programs, the reproductive performance of a dairy herd can be increased.

Schlüsselwörter

Kuh - Fruchtbarkeit - Präsynchronisation - Resynchronisation

Key words

Cow - fertility - presynchronization - resynchronization

Full Text

References

Literatur
1 Alkar A, Tibary A, Wenz JR, Nebel RL, Kasimanickam R. Presynchronization with GnRH 7 days prior to resynchronization with CO-Synch did not improve pregnancy rate in lactating dairy cows. Theriogenology 2011; 76: 1036-1041.
2 Bartolome JA, Silvestre FT, Kamimura S, Arteche ACM, Melendez P, Kelbert D, McHale J, Swift K, Archbald LF, Thatcher WW. Resynchronization of ovulation and timed insemination in lactating dairy cows I: Use of the Ovsynch and Heatsynch protocols after non-pregnancy diagnosis by ultrasonography. Theriogenology 2005; 63: 1617-1627.
3 Bartolome JA, Sozzi A, McHale J, Melendez P, Arteche ACM, Silvestre FT, Kelbert D, Swift K, Archbald LF, Thatcher WW. Resynchronization of ovulation and timed insemination in lactating dairy cows, II: Assigning protocols according to stages of the estrous cycle, or presence of ovarian cysts or anestrus. Theriogenology 2005; 63: 1628-1642.
4 Bartolome JA, Sozzi A, McHale J, Swift K, Kelbert D, Archbald LF, Thatcher WW. Resynchronization of ovulation and timed insemination in lactating dairy cows III. Administration of GnRH 23 days post AI and ultrasonography for nonpregnancy diagnosis on day 30. Theriogenology 2005; 63: 1643-1658.
5 Bello NM, Steibel JP, Pursley JR. Optimizing ovulation to first GnRH improved outcomes to each hormonal injection of Ovsynch in lactating dairy cows. J Dairy Sci 2006; 89: 3413-3424.
6 Bo GA, Adams GP, Pierson RA, Mapletoft RJ. Exogenous control of follicular wave emergence in cattle. Theriogenology 1995; 43: 31-40.
7 Burke CR, Boland MP, Macmillan KL. Ovarian responses to progesterone and estradiol benzoate administered intravaginally during dioestrus in cattle. Anim Reprod Sci 1999; 55: 23-33.
8 Cavalieri J, Eagles VE, Ryan M, Macmillan KL. Patterns of onset of oestrus and reproductive performance of dairy cows enrolled in controlled breeding programs. In: Proc Aust and NZ Comb Dairy Vet Conf, 15.-19.05.2000. Port Vila, Vanuatu: 161-182.
9 Cavalieri J, Eagles VE, Ryan M, Macmillan KL. Role of the sensitivity of detection of oestrus in the submission rate of cows treated to resynchronise oestrus. Aust Vet J 2003; 81: 416-421.
10 Chebel RC, Cerri RLA, Galvão KN, Juchem SO, Santos JEP. Effect of a rapid resynchronization of nonpregnant cows with estradiol cypionate (ECP) and PGF2 on pregnancy rates (PR) and pregnancy loss (PL) in lactating dairy cows. J Anim Sci 2003; 81 (Suppl. 01) 182 (Abstr.).
11 Chebel RC, Santos JEP, Cerri RLA, Galvão KN, Juchem SO, Thatcher WW. Effect of resynchronization with GnRH on day 21 after artificial insemination on pregnancy rate and pregnancy loss in lactating dairy cows. Theriogenology 2003; 60: 1389-1399.
12 Chebel RC, Santos JEP, Cerri RLA, Rutigliano RM, Bruno RGS. Reproduction in dairy cows following progesterone insert presynchronization and resynchronization protocols. J Dairy Sci 2006; 89: 4205-4219.
13 Chebel RC, Santos JEP. Effect of inseminating cows in estrus following a presynchronization protocol on reproductive and lactation performances. J Dairy Sci 2010; 93: 4632-4643.
14 Chenault JR, Boucher JF, Dame KJ, Meyer JA, Wood-Follis SL. Intravaginal progesterone insert to synchronize return to estrus of previously inseminated dairy cows. J Dairy Sci 2003; 86: 2039-2049.
15 Cordoba MC, Fricke PM. Evaluation of two hormonal protocols for synchronization of ovulation and timed artificial insemination in dairy cows managed in grazing-based dairies. J Dairy Sci 2001; 84: 2700-2708.
16 DeJarnette JM, Day ML, House RB, Wallace RA, Marshall CE. Effect of GnRH pretreatment on reproductive performance of postpartum suckled beef cows following synchronization of estrus using GnRH and PGF₂ . J Anim Sci 2001; 79: 1675-1682.
17 DeJarnette JM, Marshall CE. Effects of pre-synchronization using combinations PGF₂ and (or) GnRH on pregnancy rates of Ovsynch- and Cosynch-treated lactating Holstein cows. Anim Reprod Sci 2003; 77: 51-60.
18 Dewey ST, Mendonça LGD, Lopes Jr G, Rivera FA, Guagnini F, Chebel RC. Resynchronization strategies to improve fertility in lactating dairy cows utilizing a presynchronization injection of GnRH or supplemental progesterone: I. Pregnancy rates and ovarian responses. J Dairy Sci 2010; 93: 4086-4095.
19 El-Zarkouny SZ, Cartmill JA, Hensley BA, Stevenson JS. Pregnancy in dairy cows after synchronized ovulation regimens with or without presynchronization and progesterone. J Dairy Sci 2004; 87: 1024-1037.
20 El-Zarkouny SZ, Stevenson JS. Resynchronizing estrus with progesterone or progesterone plus estrogen in cows of unknown pregnancy status. J Dairy Sci 2004; 87: 3306-3321.
21 Ferguson JD, Galligan DT. Prostaglandin synchronization programs in dairy herds – Part I. Compend Contin Educ Pract Vet 1993; 15: 646-655.
22 Fricke PM, Guenther JN, Wiltbank MC. Efficacy of decreasing the dose of GnRH used in a protocol for synchronization of ovulation and timed AI in lactating dairy cows. Theriogenology 1998; 50: 1275-1284.
23 Fricke PM, Caraviello DZ, Weigel KA, Welle ML. Fertility of dairy cows after resynchronization of ovulation at three intervals following first timed insemination. J Dairy Sci 2003; 86: 3941-3950.
24 Galvão KN, Sá Filho MF, Santos JEP. Reducing the interval from presynchronization to initiation of timed artificial insemination improves fertility in dairy cows. J Dairy Sci 2007; 90: 4212-4218.
25 Galvão KN, Santos JEP. Factors affecting synchronization and conception rate after the Ovsynch protocol in lactating Holstein cows. Reprod Dom Anim 2010; 45: 439-446.
26 Gifford CA, Racicot K, Clark DS, Austin KJ, Hansen TR, Lucy MC, Davies CJ, Ott TL. Regulation of interferon-stimulated genes in peripheral blood leucocytes in pregnant and bred, nonpregnant dairy cows. J Dairy Sci 2007; 90: 274-280.
27 Ginther OJ, Kastelic JP, Knopf L. Composition and characteristics of follicular waves during the bovine estrous cycle. Anim Reprod Sci 1989; 20: 187-200.
28 Ginther OJ, Knopf L, Kastelic JP. Temporal associations among ovarian events in cattle during oestrous cycles with two and three follicular waves. J Reprod Fertil 1989; 87: 223-230.
29 Green JC, Parks TE, Avalle MP, Telugu BP, McLain AL, Peterson AJ, McMillan W, Mathialagan N, Hook RR, Xie S, Roberts RM. The establishment of an ELISA for the detection of pregnancy-associated glycoproteins (PAGs) in the serum of pregnant cows and heifers. Theriogenology 2005; 63: 1481-1503.
30 Green JC, Volkmann DH, Poock SE, McGrath MF, Erhardt M, Moseley AE, Lucy MC. Technical note: A rapid enzyme-linked immunosorbent assay blood test for pregnancy in dairy and beef cattle. J Dairy Sci 2009; 92: 3819-3824.
31 Green JC, Okamura CS, Mathew DJ, Newsom EM, Lucy MC. Hot topic: Successful fixed-time insemination within 21 d after first time insemination by combining chemical pregnancy diagnosis on d 18 with a rapid resynchronization program. J Dairy Sci 2010; 93: 5668-5672.
32 Green JC, Okamura CS, Poock SE, Lucy MC. Measurement of interferontau (IFN- ) stimulated gene expression in blood leucocytes for pregnancy diagnosis within 18–20 d after insemination in dairy cattle. Anim Reprod Sci 2010; 121: 24-33.
33 Green JC, Newsom EM, Lucy MC. Incorporation of a rapid pregnancyassociated glycoprotein ELISA into a CIDR-Ovsynch resynchronization program for a 28 day re-insemination interval. Theriogenology 2011; 75: 320-328.
34 Gümen A, Guenther JN, Wiltbank MC. Follicular size and response to Ovsynch versus detection of estrus in anovular and ovular lactating dairy cows. J Dairy Sci 2003; 86: 3184-3194.
35 Heuwieser W, Tenhagen BA, Tischer M, Lühr J, Blum H. Effect of three programmes for the treatment of endometritis on the reproductive performance of a dairy herd. Vet Rec 2000; 146: 338-341.
36 Kaneko H, Todoroki J, Noguchi J, Kikuchi K, Mizoshita K, Kubota C, Yamakuchi H. Perturbation of estradiol-feedback control of luteinizing hormone secretion by immunoneutralization induces development of follicular cysts in cattle. Biol Reprod 2002; 67: 1840-1845.
37 Keith BR, Leslie KE, Johnson WH, Walton JS. Effect of presynchronization using prostaglandin F₂ and a milk-ejection test on pregnancy rate after the timed artificial insemination protocol, Ovsynch. Theriogenology 2005; 63: 722-738.
38 LeBlanc SJ, Leslie KE. Short communication: Presynchronization using a single injection of PGF₂ before synchronized ovulation and first timed artificial insemination in dairy cows. J Dairy Sci 2003; 86: 3215-3217.
39 Long ST, Nakao T, Wakatake S, Okakoi M. Effect of CIDR 12 to 19 days after AI on detection of returning estrus and conception rate in dairy cows. J Reprod Dev 2010; 56: 251-255.
40 Lopez H, Caraviello DZ, Satter LD, Fricke PM, Wiltbank MC. Relationship between level of milk production and multiple ovulations in lactating dairy cows. J Dairy Sci 2005; 88: 2783-2793.
41 López-Gatius F, Murugavel K, Santolaria P, Yaniz J, López-Béjar M. Effects of presynchronization during the preservice period on subsequent ovarian activity in lactating dairy cows. Theriogenology 2003; 60: 545-552.
42 Lucy MC, McDougall S, Nation DP. The use of hormonal treatments to improve reproductive performance of lactating dairy cows in feedlot or pasture-based management systems. Anim Reprod Sci 2004; 82–83: 495-512.
43 Meyer JP, Radcliff RP, Rhoads ML, Bader JF, Murphy CN, Lucy MC. Timed artificial insemination of two consecutive services in dairy cows using prostaglandin F₂ and gonadotropin-releasing hormone. J Dairy Sci 2007; 90: 691-698.
44 Moreira F, de la Sota RL, Diaz T, Thatcher WW. Effect of day of the estrous cycle at the initiation of a timed artificial insemination protocol on reproductive responses in dairy heifers. J Anim Sci 2000; 78: 1568-1576.
45 Moreira F, Risco CA, Pires MFA, Ambrose JD, Drost M, Thatcher WW. Use of bovine somatotropin in lactating dairy cows receiving timed artificial insemination. J Dairy Sci 2000; 83: 1237-1247.
46 Moreira F, Orlandi C, Risco CA, Mattos R, Lopes F, Thatcher WW. Effects of presynchronization and bovine somatotropin on pregnancy rates to a timed artificial insemination protocol in lactating dairy cows. J Dairy Sci 2001; 84: 1646-1659.
47 Navanukraw C, Redmer DA, Reynolds LP, Kirsch JD, Grazul-Bilska AT, Fricke PM. A modified presynchronization protocol improves fertility to timed artificial insemination in lactating dairy cows. J Dairy Sci 2004; 87: 1551-1557.
48 Öztürk ÖA, Cirit Ü, Baran A, Ak K. Is Doublesynch protocol a new alternative for timed artificial insemination in anestrous dairy cows. Theriogenology 2010; 73: 568-576.
49 Peters MW, Pursley JR. Fertility of lactating dairy cows treated with Ovsynch after presynchronization injections of PGF₂ and GnRH. J Dairy Sci 2002; 85: 2403-2406.
50 Peters MW, Pursley JR. Timing of final GnRH of the Ovsynch protocol affects ovulatory follicle size, subsequent luteal function, and fertility. Theriogenology 2003; 60: 1197-1204.
51 Pursley JR, Mee MO, Wiltbank MC. Synchronization of ovulation in dairy cows using PGF₂ and GnRH. Theriogenology 1995; 44: 915-923.
52 Pursley JR, Kosorok MR, Wiltbank MC. Reproductive management of lactating dairy cows using synchronization of ovulation. J Dairy Sci 1997; 80: 301-306.
53 Pursley JR, Wiltbank MC, Stevenson JS, Ottobre JS, Garverick HA, Anderson LL. Pregnancy rates per artificial insemination for cows and heifers inseminated at a synchronized ovulation or synchronized estrus. J Dairy Sci 1997; 80: 295-300.
54 Rivera H, Lopez H, Fricke PM. Use of intravaginal progesterone-releasing inserts in a synchronization protocol before timed AI and for synchronizing return to estrus in Holstein heifers. J Dairy Sci 2005; 88: 957-968.
55 Rivera H, Sterry RA, Fricke PM. Presynchronization with gonadotropin-releasing hormone does not improve fertility in Holstein heifers. J Dairy Sci 2006; 89: 3810-3816.
56 Sani RN, Farzaneh N, Moezifar M, Seifi HA, Tabatabei AA. Evaluation of five resynchronization methods using different combinations of PGF2[/acute], GnRH, estradiol and an intravaginal progesterone device for insemination in Holstein cows. Anim Reprod Sci 2011; 124: 1-6.
57 Sartori R, Fricke PM, Ferreira JCP, Ginther OJ, Wiltbank MC. Follicular deviation and acquisition of ovulatory capacity in bovine follicles. Biol Reprod 2001; 65: 1403-1409.
58 Schmidt C, Gajewski Z, Wehrend A. Strategische hormonelle Fruchtbarkeitsprogramme bei Milchkühen. Teil 1: Übersicht, Ovsynch und seine Modifikationen. Tierärztl Prax 2013; 41 (G) 45-54.
59 Silva E, Sterry RA, Kolb D, Wiltbank MC, Fricke PM. Effect of pretreatment with prostaglandin F₂ before resynchronization of ovulation on fertility of lactating dairy cows. J Dairy Sci 2007; 90: 5509-5517.
60 Sirois J, Fortune JE. Lenghtening the bovine estrous cycle with low levels of progesterone: A model for studying ovarian follicular dominance. Endocrinology 1990; 127: 916-925.
61 Souza AH, Ayres H, Ferreira RM, Wiltbank MC. A new presynchronization system (Double-Ovsynch) increases fertility at first postpartum timed AI in lactating dairy cows. Theriogenology 2008; 70: 208-215.
62 Sterry RA, Welle ML, Fricke PM. Effect of interval from timed artificial insemination to initiation of resynchronization of ovulation on fertility of lactating dairy cows. J Dairy Sci 2006; 89: 2099-2109.
63 Sterry RA, Jardon PW, Fricke PM. Effect of timing of Cosynch on fertility of lactating Holstein cows after first postpartum and Resynch timed-AI services. Theriogenology 2007; 67: 1211-1216.
64 Stevenson JS, Thompson KE, Forbes WL, Lamb GC, Grieger DM, Corah LR. Synchronizing estrus and (or) ovulation in beef cows after combinations of GnRH, norgestomet, and prostaglandin F₂ with or without timed insemination. J Anim Sci 2000; 78: 1747-1758.
65 Stevenson JS, Cartmill JA, Hensley BA, El-Zarkouny SZ. Conception rates of dairy cows following early not-pregnant diagnosis by ultrasonography and subsequent treatments with shortened Ovsynch protocol. Theriogenology 2003; 60: 475-483.
66 Stevenson JS, Johnson SK, Medina-Britos MA, Richardson-Adams AM, Lamb GC. Resynchronization of estrus in cattle of unknown pregnancy status using estrogen, progesterone, or both. J Anim Sci 2003; 81: 1681-1692.
67 Stevenson JS, Tiffany SM. Resynchronizing estrus and ovulation after notpregnant diagnosis and various ovarian states including cysts. J Dairy Sci 2004; 87: 3658-3664.
68 Stevenson JS. Alternative programs to presynchronize estrous cycles in dairy cattle before a timed artificial insemination program. J Dairy Sci 2011; 94: 205-217.
69 Thatcher WW, Meyer MD, Danet-Desnoyers G. Maternal recognition of pregnancy. J Reprod Fert Suppl 1995; 49: 15-28.
70 Thompson KE, Stevenson JS, Lamb GC, Grieger M, Löest CA. Follicular, hormonal, and pregnancy responses of early postpartum suckled beef cows to GnRH, norgestomet, and prostaglandin F₂ . J Anim Sci 1999; 77: 1823-1832.
71 Van Cleeff J, Macmillan KL, Drost M, Lucy MC, Thatcher WW. Effects of administering progesterone at selected intervals after insemination of synchronized heifers on pregnancy rates and resynchronization of returns to service. Theriogenology 1996; 46: 1117-1130.
72 Vasconcelos JLM, Silcox RW, Rosa GJM, Pursley JR, Wiltbank MC. Synchronization rate, size of the ovulatory follicle, and pregnancy rate after synchronization of ovulation beginning on different days of the estrous cycle in lactating dairy cows. Theriogenology 1999; 52: 1067-1078.
73 Xu ZZ, Burton LJ. Reproductive performance of dairy heifers after estrus synchronization and fixed-time artificial insemination. J Dairy Sci 1999; 82: 910-917.